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quinupristin/dalfopristin will raise the stage or outcome of ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.quinupristin/dalfopristin will raise the amount or impact of vardenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Vardenafil dose may well must be lessened if coadministere